To determine whether baseline AIP independently predicts albuminuria progression and eGFR decline in adults with type 2 diabetes.
Key Findings:
Higher AIP was independently associated with increased hazards of kidney outcomes (adjusted HR 1.25 for albuminuria progression, 1.59 for eGFR decline).
Each standard-deviation increase in AIP correlated with a 25% increase in albuminuria progression risk and a 59% increase in sustained eGFR decline.
The highest AIP quartile was linked to more than double the risk of albuminuria progression (adjusted HR 2.09) and over three times the risk of eGFR decline (adjusted HR 3.32) compared to the lowest quartile.
Interpretation:
Limitations:
The study was conducted in a single geographic area, which may limit generalizability.
Exclusion of individuals with advanced kidney disease may affect the applicability of findings to all diabetic patients.
