Retrobulbar spot sign in non-ischemic conditions: a case series challenging its diagnostic role - Summary - MDSpire

Retrobulbar spot sign in non-ischemic conditions: a case series challenging its diagnostic role

  • By

  • Chuanjie Yin

  • Jiezhi Zhan

  • Xiliang He

  • Zhaohu Yu

  • Yu Sun

  • Shanshan Zhang

  • Huadong Lou

  • May 20, 2026

  • 0 min

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Objective:

To present three cases where the retrobulbar spot sign (RBSS) was observed in patients without confirmed central retinal artery occlusion (CRAO).

Key Findings:
  • RBSS was detected in all three patients, but only one had CRAO.
  • Two patients exhibited RBSS without evidence of CRAO.
  • RBSS remained unchanged in all four eyes during the follow-up period.
Interpretation:

RBSS may not be specific to CRAO, as it was observed in non-CRAO cases, suggesting the need for further research into its diagnostic implications and potential misinterpretations.

Limitations:
  • Small sample size of only three cases.
  • Lack of long-term follow-up data on RBSS significance.
  • Limited diversity in patient demographics.
Conclusion:

The findings challenge the notion that RBSS is exclusively indicative of CRAO, highlighting its potential presence in other ocular conditions and underscoring the need for further research.

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