Objective:

To assess and compare health-related quality of life (HRQoL) in patients with diffuse low-grade glioma (LGG) during a non-therapeutic phase, specifically comparing their HRQoL to a normative population and identifying factors contributing to impaired HRQoL.

Key Findings:

• Patients with LGG reported significant impairments in HRQoL compared to the normative population, with specific scores indicating the extent of these impairments.
• High levels of cognitive and emotional dysfunction were observed, alongside symptoms of fatigue, anxiety, and depression.
• Factors such as tumor characteristics and psychological status significantly influenced HRQoL.

Interpretation:

Despite a clinically reassuring presentation, LGG patients experience considerable challenges in HRQoL during non-therapeutic phases, highlighting the need for ongoing psychological and social support.

Limitations:

• The study was conducted at a single center, which may limit generalizability.
• Self-reported questionnaires may introduce bias in HRQoL assessment.
• Potential self-selection bias in patient responses may affect the results.

Conclusion:

Maintaining HRQoL is crucial for LGG patients during non-therapeutic periods, and further research is needed to explore long-term impacts and support strategies, particularly focusing on psychological interventions.