Impact of genetic polymorphisms in the interleukin-18 and interleukin-21 genes on the risk and clinical outcomes of multiple sclerosis - Summary - MDSpire

Impact of genetic polymorphisms in the interleukin-18 and interleukin-21 genes on the risk and clinical outcomes of multiple sclerosis

  • By

  • Noha M. Bakr

  • Noha A. Hashim

  • Mohamed Adel El-Eshmawy

  • Hatim A. El-Baz

  • May 25, 2026

  • 0 min

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Objective:

To determine whether IL-18 -137G/C (rs187238) and IL-21-1472G/T (rs2055979) SNPs impact the risk and progression of MS in Egyptian patients and their influence on clinical outcomes.

Approach:
    Key Findings:
    • The research aims to provide insights into the genetic factors influencing MS risk and progression.
    Interpretation:

    Limitations:
    • The study is limited to a specific population in Egypt, which affects the generalizability of the results.
    • Exclusion criteria limit the diversity of the patient cohort.
    Conclusion:

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