Case Report: Rapid improvement with upadacitinib in a case of paradoxical skin lesions associated with SAPHO syndrome
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By
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Jinwan Du
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Yirou Gao
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Shaohui Geng
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Chen Li
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Shike Shang
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June 4, 2026
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Objective:
To report a case of significant improvement in paradoxical skin lesions associated with SAPHO syndrome following treatment with upadacitinib.
Key Findings:
- Initial treatments with etoricoxib and methotrexate were ineffective for skin lesions.
- Adalimumab treatment led to worsening of cutaneous manifestations.
- Upadacitinib resulted in marked improvement of skin lesions and symptom relief without adverse events.
Interpretation:
Limitations:
- This is a single case report and may not be generalizable to all patients with SAPHO syndrome.
- Long-term effects and safety of upadacitinib in this context remain to be established.
Conclusion:
The findings indicate potential efficacy of upadacitinib in managing paradoxical skin lesions in patients with SAPHO syndrome.
