Objective:

To evaluate the impact of Day-3 embryo cell number on pregnancy, obstetric, and perinatal outcomes after frozen-thawed single blastocyst transfer (SBT).

Approach:

Key Findings:

• Blastocysts from Day-3 embryos with ≤5 cells had significantly lower odds of live birth compared to the 8-cell group (aOR 0.69, 95% CI 0.56–0.85).
• Blastocysts from Day-3 embryos with 6 cells also had lower odds of live birth compared to the 8-cell group (aOR 0.76, 95% CI 0.60–0.95).
• No significant differences in obstetric and perinatal outcomes were observed for ≤5-cell or 6-cell groups compared to the 8-cell group.

Interpretation:

Blastocysts derived from Day-3 embryos with ≤5 or 6 cells are associated with reduced pregnancy outcomes.

Limitations:

• Retrospective design may introduce bias.
• Exclusion of certain patient groups may limit generalizability.

Conclusion:

Findings may inform blastocyst selection during IVF treatment.

Attribution Notice

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