Construction of a nomogram combining CT and serum markers for predicting macrolide resistance gene mutation status in pediatric Mycoplasma pneumoniae pneumonia - Summary - MDSpire
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Construction of a nomogram combining CT and serum markers for predicting macrolide resistance gene mutation status in pediatric Mycoplasma pneumoniae pneumonia
To develop and validate a nomogram integrating chest CT features and serum biomarkers for predicting macrolide resistance gene mutations in pediatric Mycoplasma pneumoniae pneumonia, thereby improving treatment outcomes.
Key Findings:
MRMP group had longer fever duration (5.91 vs. 4.85 days) and hospital stay (8.77 vs. 7.32 days).
Higher rates of shortness of breath (35.86% vs. 24.38%) and oxygen requirement (25.52% vs. 13.78%) in MRMP group.
Elevated serum levels of CRP (39.16 vs. 31.74 mg/L), D-dimer (1.51 vs. 1.32 mg/L FEU), NLR (6.15 vs. 5.22), PCT (0.55 vs. 0.35 ng/mL), IL-6 (28.86 vs. 21.35 pg/mL), and LAR (9.19 vs. 8.42) in MRMP group.
CT findings showed more frequent lobar consolidation (68.28% vs. 45.23%), bilateral involvement (66.21% vs. 51.59%), and pleural effusion (32.41% vs. 14.49%) in MRMP group.
The nomogram demonstrated excellent discrimination with an AUC of 0.869.
Interpretation:
The nomogram effectively predicts macrolide resistance gene mutations in pediatric MPP, potentially improving early clinical decision-making.
Limitations:
Retrospective design may introduce selection bias and confounding factors.
Findings need validation in larger, diverse populations.
Conclusion:
The integration of CT imaging and serum biomarkers into a nomogram offers a promising tool for predicting macrolide resistance in pediatric MPP, facilitating timely treatment adjustments and improving patient outcomes.
Study found species-specific differences in biofilm -forming capacity and antimicrobial susceptibility among supragingival bacterial isolates from patients with active dental caries.
