Correlations of systemic immune-inflammation index and systemic inflammation response index with the risk for early-onset post-stroke depression in patients with minor stroke: a prospective observational study - Summary - MDSpire
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Correlations of systemic immune-inflammation index and systemic inflammation response index with the risk for early-onset post-stroke depression in patients with minor stroke: a prospective observational study
To investigate the relationship between systemic immune-inflammation index (SII), systemic inflammation response index (SIRI), and early-onset post-stroke depression (PSD) in patients with acute ischemic stroke.
Approach:
Diagnosis of Early-Onset PSD: Early-onset PSD was diagnosed 2 weeks after acute ischemic stroke using the 17-item Hamilton Depression Rating Scale (HAMD-17), with scores ≥7 indicating depression.
Statistical Analysis: Spearman rank correlation analysis evaluated associations of SII and SIRI with HAMD-17 scores. Binary logistic regression examined independent associations, and ROC analysis assessed the capacity of SII and SIRI to differentiate early-onset PSD.
Key Findings:
33.42% of the 1,113 enrolled patients were diagnosed with early-onset PSD.
HAMD-17 scores positively correlated with SII (r = 0.440, p < 0.001) and SIRI (r = 0.418, p < 0.001).
SII (OR = 1.762, 95% CI: 1.261–1.946, p < 0.001) and SIRI (OR = 1.672, 95% CI: 1.348–1.932, p = 0.004) were independent predictors of early-onset PSD.
The AUC for SII, SIRI, and their combination were 0.767, 0.718, and 0.807, respectively.
Interpretation:
SII and SIRI may serve as independent risk factors for early-onset PSD.
Limitations:
The study was conducted at a single center, which may limit generalizability.
The sample size, while significant, may still require validation in larger cohorts and could be subject to selection bias.
Conclusion:
SII and SIRI could inform prognosis management in early-onset PSD among stroke patients.
