Objective:

To examine the associations of the triglyceride-glucose waist-to-height ratio (TyG-WHtR) and its related indices with estimated glomerular filtration rate (eGFR) in a community-based elderly hypertensive population.

Approach:

Key Findings:

• 612 participants (16.25%) had reduced eGFR, indicating a significant prevalence of renal impairment in this population.
• Elevated TyG-WHtR and related indices were significant predictors of reduced eGFR, highlighting their potential role in clinical assessments.
• TyG-WHtR showed a robust association with eGFR in both pre- and post-adjustment analyses, suggesting its reliability as a marker.
• TyG-WHtR alone had an AUC of 0.596, improving to 0.864 after adjustment, demonstrating enhanced predictive capability.

Interpretation:

Elevated TyG-WHtR is an independent risk factor for the decline in eGFR in elderly patients with hypertension, demonstrating superior predictive value compared to other TyG-related indices, which may inform early intervention strategies.

Limitations:

• Cross-sectional design limits causal inference, making it difficult to establish direct relationships.
• Study conducted in a single geographic location may affect generalizability to other populations.

Conclusion:

TyG-WHtR may serve as a useful marker for early identification of renal dysfunction in elderly hypertensive patients.

Attribution Notice

This content is an AI-generated, fully rewritten summary based on a published scholarly article. It does not reproduce the original text and is not a substitute for the original publication. Readers are encouraged to consult the source for full context, data, and methodology.