Objective:

To elucidate the role of vascular smooth muscle cell (VSMC) phenotypic switching in vascular calcification (VC) and its implications for treatment.

Approach:

Key Findings:

• Vascular calcification is an active mineralization process rather than a passive accumulation.
• VSMCs undergo phenotypic switching that contributes to the calcification process.
• Matrix remodeling and mineralization are driven by various cellular and molecular mechanisms.

Interpretation:

The findings provide a theoretical foundation for developing targeted therapies for vascular calcification.

Conclusion:

The review emphasizes the complex interplay between metabolism-related calcification and suggests avenues for future research and treatment.

Attribution Notice

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