Objective:

To investigate the association between thyroid hormone sensitivity and coronary heart disease (CHD) in patients with type 2 diabetes mellitus (T2DM), specifically examining how serum albumin may mediate this relationship.

Approach:

Key Findings:

• The CHD group had significantly lower FT3/FT4 ratios and albumin levels compared to non-CHD patients.
• A decreased FT3/FT4 ratio was independently associated with CHD.
• The FT3/FT4 ratio showed modest discriminative ability for CHD (AUC = 0.740).
• Albumin partially mediated the association between peripheral TH sensitivity and CHD, accounting for 19.3% of the total effect.

Interpretation:

Impaired peripheral thyroid hormone sensitivity is positively associated with CHD in T2DM, suggesting that serum albumin may play a significant role as a biological mediator in this relationship.

Limitations:

• The study's cross-sectional design limits causal inferences, making it difficult to establish a direct cause-and-effect relationship.
• The sample was limited to hospitalized patients, which may not represent the broader T2DM population, potentially affecting the generalizability of the findings.

Conclusion:

Impaired peripheral thyroid hormone sensitivity is associated with CHD in T2DM, with serum albumin possibly mediating this relationship.

Attribution Notice

This content is an AI-generated, fully rewritten summary based on a published scholarly article. It does not reproduce the original text and is not a substitute for the original publication. Readers are encouraged to consult the source for full context, data, and methodology.