Reversing Epigenetic Changes in Skin Aging to Enhance Longevity Across Various Ethnicities and Skin Types with a Dihydromyricetin-Enriched Serum: Findings from a Prospective Cohort Investigation - Summary - MDSpire

Reversing Epigenetic Changes in Skin Aging to Enhance Longevity Across Various Ethnicities and Skin Types with a Dihydromyricetin-Enriched Serum: Findings from a Prospective Cohort Investigation

  • By

  • Minyue Qi

  • Paula Pitta

  • Katrin Wegner

  • Boris Kristof

  • Yan Feng

  • Günter Raddatz

  • Manuel Rodríguez-Paredes

  • Julia Gallinger

  • Rungsima Wanitphakdeedecha

  • Marc Winnefeld

  • Lilia Guadanhim

  • Cheri Frey

  • Frank Lyko

  • Cassandra Falckenhayn

  • Elke Grönniger

  • April 25, 2026

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Objective:

To investigate whether epigenetic mechanisms related to skin aging are conserved across diverse ethnicities and phototypes, and to evaluate the effects of dihydromyricetin (DHM) on reversing these changes.

Approach:
    Key Findings:
    • Epigenetic aging signatures are conserved across different ethnicities, suggesting a universal mechanism.
    • Topical application of DHM significantly reverses biological skin age, indicating its potential as an anti-aging treatment.
    • DHM improves visible and structural signs of aging, enhancing overall skin appearance.
    Interpretation:

    The study supports the hypothesis that epigenetic mechanisms of skin aging are universal across ethnicities, and that DHM can be an effective intervention for skin longevity.

    Limitations:
    • The small sample size in the pilot study limits the generalizability of the findings.
    • The product-use study's demographic representation may not fully capture the diversity of skin aging across all ethnicities.
    Conclusion:

    Epigenetic rejuvenation using DHM presents a promising strategy for enhancing skin longevity across diverse ethnicities and phototypes, potentially transforming anti-aging interventions.

Original Source(s)

Reversing Epigenetic Changes in Skin Aging to Enhance Longevity Across Various Ethnicities and Skin Types with a Dihydromyricetin-Enriched Serum: Findings from a Prospective Cohort Investigation

  • by Minyue Qi, Paula Pitta, Katrin Wegner, Boris Kristof, Yan Feng, Günter Raddatz, Manuel Rodríguez-Paredes, Julia Gallinger, Rungsima Wanitphakdeedecha, Marc Winnefeld, Lilia Guadanhim, Cheri Frey, Frank Lyko, Cassandra Falckenhayn, Elke Grönniger

  • April 25, 2026

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