Objective:

To evaluate the association between low-density line (LDL) extent and time to fracture in children with congenital anterolateral bowing of the tibia.

Approach:

Key Findings:

• Fractures occurred in 31 out of 40 children (77.5%).
• 61.3% of fractures occurred within 6 months after LDL detection.
• Kaplan–Meier analysis showed significant differences in fracture-free survival among LDL proportion groups (P = 0.014).
• Median times to fracture were 567 days for 2/3 LDL groups.
• Univariable Cox regression indicated larger LDL proportion was associated with shorter time to fracture (P = 0.021).

Interpretation:

The clustering of fracture events within the first 6 months after LDL detection suggests a potential period for closer monitoring.

Limitations:

• Study is retrospective and conducted at a single center, which may limit generalizability.
• Sample size may limit the generalizability of findings.
• Multivariable adjustment attenuated the association between LDL proportion and fracture timing.

Conclusion:

LDL proportion may be associated with earlier fracture timing in pediatric ALBT patients, highlighting the need for further validation in larger prospective studies.

Attribution Notice

This content is an AI-generated, fully rewritten summary based on a published scholarly article. It does not reproduce the original text and is not a substitute for the original publication. Readers are encouraged to consult the source for full context, data, and methodology.