Comparative analysis of stereotactic radiosurgery and microsurgery for vestibular schwannoma: a clinical and radiological evaluation - Summary - MDSpire

Comparative analysis of stereotactic radiosurgery and microsurgery for vestibular schwannoma: a clinical and radiological evaluation

  • By

  • Andre E. Boyke

  • Tariq Al-Saadi

  • Simon A. Menaker

  • Edward Robinson

  • Alan Nguyen

  • Michelot Michel

  • Brittany Morris

  • Younis Al-Mufargi

  • Behrooz Hakimian

  • Amin Mirhadi

  • Yu-Tung Wong

  • Mia E. Miller

  • John S. Yu

  • July 18, 2026

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Objective:

To compare clinical and radiological outcomes of patients with vestibular schwannomas treated with either stereotactic radiosurgery (SRS) or microsurgery over an eleven-year period.

Approach:
  • Study Design: Retrospective cohort study analyzing medical records and radiographs of patients treated for vestibular schwannomas from 2013 to 2024.
  • Data Collection: Collected parameters included patient demographics, clinical symptoms, radiographic features, and treatment type.
  • Statistical Analysis: Used IBM SPSS Statistics for analysis with appropriate statistical tests to assess significance.
Key Findings:
  • SRS patients were older than microsurgery patients (mean age 59.47 vs. 52.36 years, p = 0.037).
  • No significant differences in sexual distribution or preoperative facial weakness and hearing loss between groups (p = 0.740).
  • Microsurgery patients had a higher occurrence of brainstem compression (p = 0.017).
  • Postoperative facial weakness and hearing loss showed no differences between treatment groups.
  • Microsurgery resulted in significant tumor shrinkage (76.04%), while SRS patients demonstrated tumor stability or slight growth.
Interpretation:

Differences in outcomes between SRS and microsurgery for vestibular schwannomas were observed, particularly regarding tumor response and patient demographics.

Limitations:
  • Retrospective design may introduce variability in documentation and data collection.
  • Inconsistent availability of detailed SRS parameters and follow-up intervals.
Conclusion:

The findings indicate that tumor characteristics and patient demographics may influence treatment outcomes for vestibular schwannomas.

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