To quantitatively synthesize the association between maternal blood lipid levels and the risk of preeclampsia (PE), and to evaluate its potential clinical utility for risk stratification monitoring.
Key Findings:
HDL levels were significantly lower in PE patients (SMD = −0.14, 95% CI: −0.18 to −0.10, P < 0.05).
LDL, TG, and TC levels were significantly elevated in PE patients (SMD for LDL = 0.44, 95% CI: 0.32–0.55, P < 0.05; TG = 0.47, 95% CI: 0.36–0.59, P < 0.05; TC = 0.24, 95% CI: 0.18–0.31, P < 0.05).
The incidence of adverse pregnancy outcomes was significantly higher in the PE group (OR = 3.90, 95% CI: 2.62–5.81, P < 0.00001).
Interpretation:
Patients with PE exhibit alterations in blood lipid levels, persisting after BMI adjustment.
Limitations:
Causal inference is precluded due to the observational nature of the included studies.
Effect sizes are modest and may not fully capture the complexity of lipid metabolism in PE.
Conclusion:
Remove unsupported claims about clinical reference in PE management.
