Assessing the association of physical distancing to avoid COVID-19 with health-related quality of life in immunocompromised adolescents: results from the cross-sectional observational EAGLE study - Summary - MDSpire

Assessing the association of physical distancing to avoid COVID-19 with health-related quality of life in immunocompromised adolescents: results from the cross-sectional observational EAGLE study

  • By

  • Paul Williams

  • Timothy A. Herring

  • Renata T. C. Yokota

  • Sudhir Venkatesan

  • Klas Bergenheim

  • Johan L. Severens

  • Philip A. Powell

  • James C. Marcus

  • Stephanie Philpott

  • Sara Bestea

  • Jeffrey M. Rohay

  • Tiago Maia

  • Sylvia Taylor

  • Marieke Krol

  • James W. Varni

  • May 28, 2026

  • 0 min

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Objective:

To describe physical distancing behaviors to avoid COVID-19 and their associations with health-related quality of life (HRQoL) and related outcomes among immunocompromised adolescents aged 13 to 17 years.

Key Findings:
  • Among 405 immunocompromised adolescents, the mean T-score for physical distancing was 49.1, indicating moderate intensity.
  • 60.1% reported moderate physical distancing intensity, while 16.3% reported high/very high intensity.
  • The mean total score for HRQoL was 58.0, with moderate correlations between physical distancing and various outcomes (|r| = 0.4–0.5).
  • Stronger correlations were found for activity impairment, school presenteeism, and overall school impairment (|r|>0.6).
Interpretation:

Higher intensities of physical distancing were associated with worse HRQoL and greater school and activity impairment among immunocompromised adolescents, highlighting the need for tailored public health strategies.

Limitations:
  • The study is cross-sectional, limiting causal inferences.
  • Self-reported data may introduce bias.
  • Findings may not be generalizable to all immunocompromised adolescents.
Conclusion:

Most immunocompromised adolescents practiced moderate-to-high physical distancing to avoid COVID-19, which was associated with negative impacts on HRQoL and daily activities.

Original Source(s)

Assessing the association of physical distancing to avoid COVID-19 with health-related quality of life in immunocompromised adolescents: results from the cross-sectional observational EAGLE study

  • by Paul Williams, Timothy A. Herring, Renata T. C. Yokota, Sudhir Venkatesan, Klas Bergenheim, Johan L. Severens, Philip A. Powell, James C. Marcus, Stephanie Philpott, Sara Bestea, Jeffrey M. Rohay, Tiago Maia, Sylvia Taylor, Marieke Krol, James W. Varni

  • May 28, 2026

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