Biological effects of 18F-FDG administration and CT dose during PET/CT: chromosomal aberrations in a two-center prospective observational study - Summary - MDSpire

Biological effects of 18F-FDG administration and CT dose during PET/CT: chromosomal aberrations in a two-center prospective observational study

  • By

  • Yuri Kawashima

  • Yasuha Kinugasa

  • Mana Ishibashi

  • Wataru Fukumoto

  • Yoshihiro Miyata

  • Reiko Ideguchi

  • Chiemi Sakai

  • Mari Ishida

  • Seiko Hirota

  • Shinji Yoshinaga

  • Ikuno Nishibuchi

  • Yuji Murakami

  • Gloriamaris Loy-Caraos

  • Namkhai Bayasgalan

  • Suvd Bayarjargal

  • Lin Shi

  • Jiying Sun

  • Yasunori Horikoshi

  • Morihito Okada

  • Yuko Nakamura

  • Kazuo Awai

  • Takashi Kudo

  • Satoshi Tashiro

  • July 17, 2026

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Objective:

To quantitatively distinguish the acute biological contributions of internal FDG exposure and external CT exposure using chromosomal aberration (CA) analysis and to define a biologically acceptable CT dose range for PET/CT.

Approach:
  • Study Design: A prospective two-center observational study was conducted with patients undergoing FDG-PET/CT at Hiroshima University Hospital (reduced-dose protocol) and Nagasaki University Hospital (standard-dose protocol).
  • Participants: 101 patients from Center RD and 56 patients from Center SD were enrolled, primarily for oncologic evaluation.
  • PET/CT Protocol: Whole-body PET/CT scans were performed using Biograph mCT scanners with specific CT parameters for each center.
  • Blood Sampling: Peripheral blood samples were collected at three time points: pre-FDG, post-FDG, and post-CT for chromosomal analysis.
Key Findings:
  • The study utilized a high-sensitivity CA assay to measure chromosomal aberrations as biomarkers of radiation exposure.
  • Reduced-dose CT protocols demonstrated biological superiority compared to standard-dose protocols based on chromosomal aberration analysis.
Interpretation:

Limitations:
  • The study excluded patients with a history of radiation therapy and those with lymphoma and myeloma, which may limit generalizability.
  • The observational nature of the study may introduce confounding factors.
Conclusion:

The study supports the use of chromosomal aberration analysis in evaluating biological effects of radiation exposure in PET/CT settings.

Original Source(s)

Biological effects of 18F-FDG administration and CT dose during PET/CT: chromosomal aberrations in a two-center prospective observational study

  • by Yuri Kawashima, Yasuha Kinugasa, Mana Ishibashi, Wataru Fukumoto, Yoshihiro Miyata, Reiko Ideguchi, Chiemi Sakai, Mari Ishida, Seiko Hirota, Shinji Yoshinaga, Ikuno Nishibuchi, Yuji Murakami, Gloriamaris Loy-Caraos, Namkhai Bayasgalan, Suvd Bayarjargal, Lin Shi, Jiying Sun, Yasunori Horikoshi, Morihito Okada, Yuko Nakamura, Kazuo Awai, Takashi Kudo, Satoshi Tashiro

  • July 17, 2026

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