Non-gestational choriocarcinoma presenting as cervical lymphadenopathy in a male patient: a case report - Summary - MDSpire

Non-gestational choriocarcinoma presenting as cervical lymphadenopathy in a male patient: a case report

  • By

  • Xiaoming Li

  • Daiying Gui

  • Chen Xie

  • Yunhong Xia

  • June 29, 2026

  • 0 min

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Objective:

To report a rare case of non-gestational choriocarcinoma (NGCC) in a male patient presenting with cervical lymphadenopathy and discuss the associated diagnostic challenges.

Approach:
  • Case Presentation: A 38-year-old male presented with a painless mass in the left cervical region that had persisted for more than one year, with elevated serum β-hCG and extensive lymph node involvement.
Key Findings:
  • NGCC is a rare and aggressive malignancy in males, often diagnosed at an advanced stage.
  • Cervical lymphadenopathy can be the initial manifestation of NGCC, complicating diagnosis.
  • Elevated β-hCG levels are a key indicator for diagnosing NGCC.
Interpretation:

Early recognition of NGCC is crucial, particularly when patients present with unexplained cervical lymphadenopathy and elevated β-hCG levels.

Limitations:
  • The rarity of NGCC in males may limit generalizability of findings.
  • The case highlights challenges in diagnosis due to atypical presentations, including the potential for misdiagnosis.
Conclusion:

This case emphasizes the need for comprehensive evaluation in male patients with cervical lymphadenopathy to avoid diagnostic delays.

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