Are We Too Afraid of Our Instruments?
An obsession with spotless systems means we risk working for our instruments, rather than the other way around
By
Jennifer Field
June 29, 2026
Objective: To encourage analytical scientists to deeply understand their instruments and explore creative methodologies in their research.
Approach: Understanding Instruments: Emphasizes the importance of knowing instruments intimately to enhance their use in research.Innovative Techniques: Discusses unconventional methods like large-volume injection and in situ experiments to improve workflow and sensitivity.Critical Evaluation of Cleanup Steps: Critiques the habitual use of solid-phase extraction and advocates for simpler alternatives when appropriate.Key Findings: In-depth knowledge of instruments can lead to innovative research approaches, as demonstrated in PFAS research. Simplifying workflows, such as through large-volume injection, can improve efficiency and reduce costs. Understanding when cleanup steps are necessary is crucial to avoid unnecessary complexity and waste. Interpretation: Encourages a balance between maintaining instrument cleanliness and exploring creative methodologies in research.
Limitations: The article does not provide empirical data to support claims about the effectiveness of alternative methods. The insights may not apply universally to all laboratory settings or types of analyses. Conclusion: A deep understanding and creative use of instruments can enhance research outcomes, while unnecessary cleanup steps should be minimized.