The Changing Landscape of Maintenance Therapy in Newly Diagnosed Multiple Myeloma: A Systematic Review With Network Meta-Analysis of the European Myeloma Network (EMN) - Summary - MDSpire
Coming Soon: Introducing MDSpire News. Learn more
Conexiant’s news site is now MDSpire News. Learn more

Evolving Approaches to Maintenance Therapy in Newly Diagnosed Multiple Myeloma: A Systematic Review and Network Meta-Analysis from the European Myeloma Network (EMN)

  • By

  • Heinz Ludwig

  • Evangelos Terpos

  • Francesca Gay

  • Niels W. C. J. van de Donk

  • Sarah Bernhard

  • Monika Engelhardt

  • Gordon Cook

  • Fredrik Schjesvold

  • Hermann Einsele

  • Graham Jackson

  • Charlotte Pawlyn

  • María-Victoria Mateos

  • Sonja Zweegman

  • Martin Schreder

  • Meral Beksaç

  • Christoph Driessen

  • Enrique M. Ocio

  • Rakesh Popat

  • Leo Rasche

  • Cyrille Touzeau

  • Pellegrino Musto

  • Annemiek Broijl

  • Meletios Dimopoulos

  • Roman Hajek

  • Mario Boccadoro

  • Pieter Sonneveld

  • June 18, 2026

Share

Objective:

To review current evidence on maintenance therapy for newly diagnosed multiple myeloma and conduct a systematic review and network meta-analysis for treatment comparison.

Approach:
  • Literature Review: Literature for this analysis was retrieved by searching PubMed, EMBASE, and the Cochrane Library up to November 2025. Articles were excluded if irrelevant to the research question, lacking a control group, using outdated treatment regimens, or missing PFS data.
Key Findings:
  • Lenalidomide maintenance post-ASCT is established as standard care, improving PFS and OS.
  • Continuous treatment in transplant-ineligible patients shows significant benefits in PFS and OS.
  • Emerging immune and cellular therapies are being investigated for maintenance therapy.
Interpretation:

The study analyzes maintenance therapy options for newly diagnosed multiple myeloma, highlighting established and novel treatments.

Limitations:
  • Exclusion of studies lacking control groups or relevant data.
  • Potential biases in selected studies assessed using the Cochrane Risk of Bias tool.
Conclusion:

The findings highlight the need for robust comparisons of maintenance therapies.

Original Source(s)

The Changing Landscape of Maintenance Therapy in Newly Diagnosed Multiple Myeloma: A Systematic Review With Network Meta-Analysis of the European Myeloma Network (EMN)

  • by Heinz Ludwig, Evangelos Terpos, Francesca Gay, Niels W. C. J. van de Donk, Sarah Bernhard, Monika Engelhardt, Gordon Cook, Fredrik Schjesvold, Hermann Einsele, Graham Jackson, Charlotte Pawlyn, María-Victoria Mateos, Sonja Zweegman, Martin Schreder, Meral Beksaç, Christoph Driessen, Enrique M. Ocio, Rakesh Popat, Leo Rasche, Cyrille Touzeau, Pellegrino Musto, Annemiek Broijl, Meletios Dimopoulos, Roman Hajek, Mario Boccadoro, Pieter Sonneveld

  • June 18, 2026

Related Content

Cost-Effectiveness of Smoking Cessation Interventions Integrated Into Lung Cancer Screening

Personalized Cancer Vaccine Linked to Three-Year Disease-Free Survival in Head and Neck Cancer

All 16 patients who received TG4050 after standard treatment remained disease-free, compared with 13 of 16 patients in the control group

  • September 16, 2026

  • 2 min
Intraoperative Evaluation of Sarcoma Surgical Margins With Indocyanine Green Fluorescence Imaging: Results From an Observational Study