Thrombectomy for Acute Stroke Due to Medium Vessel Occlusion Across Perfusion Mismatch Profiles: A Post Hoc - Summary - MDSpire
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Thrombectomy for Acute Stroke From Medium Vessel Occlusion Across Perfusion Mismatch Patterns: A Post Hoc Analysis

  • By

  • Umberto Pensato

  • Gunjan Jindal

  • William Diprose

  • Aravind Ganesh

  • Pattarawut Charatpangoon

  • Ethan MacDonald

  • Alexander Stebner

  • Salome Bosshart

  • Dar Dowlatshahi

  • David Volders

  • James Kennedy

  • Markus Möhlenbruch

  • Brian H. Buck

  • Shahid Nimjee

  • Thomas Booth

  • Mouhammad Jumaa

  • Jai J. Shankar

  • Franziska Dorn

  • Andrew M. Demchuk

  • Mayank Goyal

  • Michael D. Hill

  • Johanna M. Ospel

  • ESCAPE-MEVO Investigators

  • Jennifer Mandzia

  • Sachin Pandey

  • Jesse Klostranec

  • Lissa Peeling

  • Joanna Schaafsma

  • Timo Krings

  • Atif Zafar

  • Ravinder-Jeet Singh

  • Demetrios Sahlas

  • Thalia Field

  • Richard Swartz

  • Pual (Inder) Singh

  • Koji Ebersole

  • Negar Asdashi

  • Dileep Yavagal

  • Reade De Leacy

  • George Lopez

  • Babak Jahromi

  • Ronald Budzik

  • Seon-Kyu Lee

  • Eric Sauvageau

  • Adewumi Amole

  • Maxim Mokin

  • Mchael Levitt

  • Jason Tarpley

  • Albert Yoo

  • Michael Chen

  • Thanhn Nguyen

  • Santiago Ortega-Gutierrez

  • Adnan Siddiqui

  • Fabio Settecase

  • Thien Huynh

  • Tufail Patankar

  • Levansri Makalanda

  • Paul Burns

  • Changez Jadun

  • Aubrey Smith

  • Kyriakos Lobotesis

  • Rob Crossley

  • Robert Lenthall

  • Thant Hlaing

  • Ayokunle Ogungbemi

  • Liqun Zhang

  • Richard Marigold

  • Yogish Joshi

  • Richard Perry

  • Christian Hametner

  • Sven Poli

  • Joerg Berrouschot

  • Christian Taschner

  • Arno Reich

  • Hauke Scheider

  • Sandor Nardai

  • Gabor Lenzser

  • October 13, 2026

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Objective:

To assess whether perfusion mismatch profiles are associated with functional outcomes after medium vessel occlusion (MeVO) stroke and whether they modify the effect of endovascular thrombectomy (EVT).

Approach:
  • Study design: Post hoc analysis of the ESCAPE-MeVO randomized clinical trial, comparing EVT plus medical therapy with medical therapy alone.
  • Participants: Included trial participants with interpretable baseline perfusion imaging and an available 90-day modified Rankin Scale (mRS) score.
  • Measures: Perfusion mismatch volume was calculated as Tmax >6-second volume minus ischemic core volume; mismatch ratio was Tmax >6-second volume divided by core volume. The primary outcome was ordinal 90-day mRS.
Interpretation:

The provided article context describes the study rationale, design, eligibility, imaging measures, and outcomes but does not report analysis results.

Limitations:
  • The supplied context ends before the statistical analysis and results, so findings and study-specific limitations cannot be summarized.
Sources:

Original Source(s)

Thrombectomy for Acute Stroke Due to Medium Vessel Occlusion Across Perfusion Mismatch Profiles: A Post Hoc

  • by Umberto Pensato, Gunjan Jindal, William Diprose, Aravind Ganesh, Pattarawut Charatpangoon, Ethan MacDonald, Alexander Stebner, Salome Bosshart, Dar Dowlatshahi, David Volders, James Kennedy, Markus Möhlenbruch, Brian H. Buck, Shahid Nimjee, Thomas Booth, Mouhammad Jumaa, Jai J. Shankar, Franziska Dorn, Andrew M. Demchuk, Mayank Goyal, Michael D. Hill, Johanna M. Ospel, ESCAPE-MEVO Investigators, Jennifer Mandzia, Sachin Pandey, Jesse Klostranec, Lissa Peeling, Joanna Schaafsma, Timo Krings, Atif Zafar, Ravinder-Jeet Singh, Demetrios Sahlas, Thalia Field, Richard Swartz, Pual (Inder) Singh, Koji Ebersole, Negar Asdashi, Dileep Yavagal, Reade De Leacy, George Lopez, Babak Jahromi, Ronald Budzik, Seon-Kyu Lee, Eric Sauvageau, Adewumi Amole, Maxim Mokin, Mchael Levitt, Jason Tarpley, Albert Yoo, Michael Chen, Thanhn Nguyen, Santiago Ortega-Gutierrez, Adnan Siddiqui, Fabio Settecase, Thien Huynh, Tufail Patankar, Levansri Makalanda, Paul Burns, Changez Jadun, Aubrey Smith, Kyriakos Lobotesis, Rob Crossley, Robert Lenthall, Thant Hlaing, Ayokunle Ogungbemi, Liqun Zhang, Richard Marigold, Yogish Joshi, Richard Perry, Christian Hametner, Sven Poli, Joerg Berrouschot, Christian Taschner, Arno Reich, Hauke Scheider, Sandor Nardai, Gabor Lenzser

  • October 13, 2026

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