Propensity Score–Weighted Analysis of the Impact of Outpatient Parenteral Antimicrobial Therapy Plan Reconciliation on Unscheduled Care - Summary - MDSpire

Propensity Score–Weighted Analysis of the Impact of Outpatient Parenteral Antimicrobial Therapy Plan Reconciliation on Unscheduled Care

  • By

  • Jennifer K Ross

  • William D Sieling

  • Kaylyn N Billmeyer

  • Elizabeth B Hirsch

  • Michael D Evans

  • Susan E Kline

  • Alison L Galdys

  • June 12, 2025

  • 0 min

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Objective:

To analyze the impact of ID pharmacist reconciliation of OPAT plans on unscheduled healthcare utilization, specifically focusing on emergency department visits, hospital readmissions, and mortality within 90 days post-discharge.

Key Findings:
  • Postimplementation patients had fewer ED visits (17.8% vs. 22.2%, P = .02).
  • Postimplementation patients had fewer hospital readmissions (33.4% vs. 38.9%, P = .01).
  • No significant difference in 90-day all-cause mortality between cohorts (P > .05).
Interpretation:

The implementation of OPAT plan reconciliation by ID pharmacists significantly reduced unscheduled healthcare utilization among OPAT recipients, highlighting the importance of medication safety.

Limitations:
  • Retrospective design may introduce selection bias, potentially affecting the generalizability of results.
  • Data on long-term outcomes beyond 90 days were not assessed, limiting the understanding of the intervention's full impact.
  • Potential confounding factors not fully controlled despite propensity score weighting may influence outcomes.
Conclusion:

ID pharmacist reconciliation of OPAT plans prior to discharge is associated with reduced ED visits and readmissions, underscoring its critical role in enhancing medication safety during transitions of care.

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