Association of the sdLDL-C/lbLDL-C ratio with heart failure beyond conventional LDL-C levels: a cross-sectional study - Summary - MDSpire

Association of the sdLDL-C/lbLDL-C ratio with heart failure beyond conventional LDL-C levels: a cross-sectional study

  • By

  • Xuyang Pan

  • Fang Liu

  • Wei Li

  • Tao Li

  • Changgao Zhou

  • Liting Yang

  • Yanchun Zhang

  • Xingyu Zhu

  • Lina Zheng

  • Yihan Zhou

  • Xue Sun

  • Shushen Ji

  • Yue Wang

  • Jiangman Zhao

  • Guoliang Yuan

  • July 17, 2026

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Objective:

To explore the association between blood lipid profile and heart failure (HF).

Approach:
  • Study Design: A cross-sectional analysis involving 584 newly diagnosed HF patients and 611 non-HF controls.
  • Data Collection: Clinical characteristics and routine lipid parameters were collected, and LDL-C subfractions were quantified.
  • Statistical Analysis: Multivariable logistic regression analysis was performed to identify independent correlates of HF.
Key Findings:
  • HF patients had significantly higher sdLDL-C levels and lower lbLDL-C levels compared to controls.
  • The sdLDL-C/lbLDL-C ratio was significantly higher in HF patients.
  • The sdLDL-C/lbLDL-C ratio was identified as an independent factor associated with HF (OR = 2.199, 95% CI: 1.293–3.874, P < 0.001).
Interpretation:

Lipoprotein subfraction characteristics, particularly the sdLDL-C/lbLDL-C ratio, are associated with HF status and cardiac function.

Limitations:
  • The study is observational and may not establish causality.
  • The sample was limited to a specific hospital, which may affect generalizability.
Conclusion:

The sdLDL-C/lbLDL-C ratio may serve as a marker for assessing heart failure status.

Original Source(s)

Association of the sdLDL-C/lbLDL-C ratio with heart failure beyond conventional LDL-C levels: a cross-sectional study

  • by Xuyang Pan, Fang Liu, Wei Li, Tao Li, Changgao Zhou, Liting Yang, Yanchun Zhang, Xingyu Zhu, Lina Zheng, Yihan Zhou, Xue Sun, Shushen Ji, Yue Wang, Jiangman Zhao, Guoliang Yuan

  • July 17, 2026

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