Relationship Between the sdLDL-C/lbLDL-C Ratio and Heart Failure Independent of Traditional LDL-C Levels: A Cross-Sectional Analysis

To explore the association between blood lipid profile and heart failure (HF).

Study Design: A cross-sectional analysis involving 584 newly diagnosed HF patients and 611 non-HF controls.
Data Collection: Clinical characteristics and routine lipid parameters were collected, and LDL-C subfractions were quantified.
Statistical Analysis: Multivariable logistic regression analysis was performed to identify independent correlates of HF.

HF patients had significantly higher sdLDL-C levels and lower lbLDL-C levels compared to controls.
The sdLDL-C/lbLDL-C ratio was significantly higher in HF patients.
The sdLDL-C/lbLDL-C ratio was identified as an independent factor associated with HF (OR = 2.199, 95% CI: 1.293–3.874, P < 0.001).

Lipoprotein subfraction characteristics, particularly the sdLDL-C/lbLDL-C ratio, are associated with HF status and cardiac function.

The study is observational and may not establish causality.
The sample was limited to a specific hospital, which may affect generalizability.

The sdLDL-C/lbLDL-C ratio may serve as a marker for assessing heart failure status.