To investigate intraocular pressure (IOP) changes during hemodialysis in patients with end-stage kidney disease (ESKD).
Approach:
Study Design: A prospective study monitoring 103 eyes from 56 patients receiving maintenance hemodialysis, tracking IOP changes at five time points during and after dialysis.
Key Findings:
Mean IOP increased from 14.9 mmHg at baseline to 17.5 mmHg after four hours of hemodialysis, returning to near baseline 30 minutes post-treatment.
Mean ocular perfusion pressure (MOPP) declined from 56.9 mmHg at baseline to 47.2 mmHg at four hours.
Approximately 25% of eyes experienced a clinically significant IOP rise of more than 5 mmHg during dialysis, with mean values exceeding 21 mmHg in these cases.
Patients with pre-dialysis serum osmolality above 312 mOsm/kg were over three times more likely to develop significant IOP rises.
Interpretation:
Conclusion:
The findings highlight the importance of monitoring intra-dialytic ocular physiology in patients with glaucoma or ocular hypertension.
FOXC1 duplications were the second most common monogenic finding among genetically solved juvenile open-angle glaucoma cases in one registry, supporting the use of copy-number variant analysis in early-onset glaucoma testing.
