Editorial Expression of Concern: Evidence from a genetic fate-mapping study that stem cells refresh adult mammalian cardiomyocytes after injury - Summary - MDSpire
To inform readers about concerns raised regarding certain blots in the original study.
Approach:
Figure Analysis: Concerns were specifically noted regarding the blots in Fig. 1b and Fig. 3a, including issues of overlap and image interchange.
Key Findings:
Partial overlap was observed in Fig. 1b among various doses of GFP, including 7 doses and 14 doses with color separation.
The authors indicated that images labeled 'MI remote' and 'Overload' in Fig. 3a were interchanged during assembly.
Interpretation:
Readers are advised to interpret the results cautiously due to the raised concerns.
Limitations:
Original images for Fig. 1b could not be retrieved by the authors.
The authors acknowledged the interchange of images in Fig. 3a.
Conclusion:
An Editorial Express of Concern has been issued, supported by Richard T Lee, Jeffery D Molkentin, Catherine MacGillivray, Michael E Davis, Vincent F M Segers, and Patrick C H Hsieh.
by Patrick C. H. Hsieh, Vincent F. M. Segers, Michael E. Davis, Catherine MacGillivray, Joseph Gannon, Jeffery D. Molkentin, Jeffrey Robbins, Richard T. Lee
Guideline recommends screening, diagnosis, positive airway pressure therapy, and postpartum reassessment while highlighting the very low certainty of available evidence.
Modeling of nationally representative US data suggested broader implementation of the AHA/ACC 's 2025 recommendations could expand antihypertensive treatment eligibility and reduce long-term mortality among high-risk adults.
