Objective:

To propose a conceptual framework for understanding immune evasion in gastric and colorectal cancers, focusing on spatial immune archetypes that influence immunotherapy outcomes.

Approach:

Key Findings:

• Immunotherapy outcomes are influenced by multicellular architectures rather than lymphocyte abundance alone.
• Four spatial immune archetypes were identified: stromal-excluded barrier niche, myeloid-suppressive metabolic niche, inflamed lymphoid-reactive niche, and epithelial-immune interface niche.
• Tissue-specific anatomical constraints and distinct microbial ecologies shape the prevalence of these archetypes.

Interpretation:

Limitations:

• Current profiling methods fail to capture the complexity of tissue architecture and immune interactions.
• Bulk and single-cell profiling techniques may obscure important spatial dynamics and functional outputs.

Conclusion:

Understanding spatial immune archetypes provides a framework for addressing resistance to immunotherapy in gastric and colorectal cancers.

Attribution Notice

This content is an AI-generated, fully rewritten summary based on a published scholarly article. It does not reproduce the original text and is not a substitute for the original publication. Readers are encouraged to consult the source for full context, data, and methodology.