One-year breakthrough SARS-CoV-2 infection and correlates of protection in fully vaccinated hematological patients - Summary - MDSpire

One-year breakthrough SARS-CoV-2 infection and correlates of protection in fully vaccinated hematological patients

  • By

  • José Luis Piñana

  • Lourdes Vazquez

  • Marisa Calabuig

  • Lucia López-Corral

  • Gabriel Martin-Martin

  • Lucia Villalon

  • Gabriela Sanz-Linares

  • Venancio Conesa-Garcia

  • Andrés Sanchez-Salinas

  • Beatriz Gago

  • Ana Facal

  • Irene Risco-Gálvez

  • María T. Olave

  • Ildefonso Espigado

  • Javier Lopez-Jimenez

  • José Ángel Hernández-Rivas

  • Alejandro Avendaño-Pita

  • Ignacio Arroyo

  • Elena Ferrer

  • Irene García-Cadenas

  • Clara González-Santillana

  • Alicia Roldán-Pérez

  • Blanca Ferrer

  • Manuel Guerreiro

  • María Suarez-Lledó

  • Angela Camara

  • Diana Campos-Beltrán

  • David Navarro

  • Ángel Cedillo

  • Anna Sureda

  • Carlos Solano

  • Rodrigo Martino

  • January 5, 2023

  • 0 min

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Objective:

To analyze the incidence, characteristics, severity, and clinical and immune factors associated with breakthrough SARS-CoV-2 infections in fully vaccinated hematological patients over one year, emphasizing the prospective nature of the study.

Key Findings:
  • Breakthrough COVID-19 infections occurred in vaccinated hematological patients, with a mortality rate of 12.4%. High hospitalization (66.4%) and ICU admission (21.3%) rates were observed despite vaccination, particularly with the Omicron variant, highlighting the variant's implications.
Interpretation:

The findings indicate that while vaccination reduces mortality in hematological patients, breakthrough infections remain common and severe, necessitating ongoing monitoring and potential booster strategies tailored for this population.

Limitations:
  • High rates of missing serological data over time may affect the robustness of the findings, particularly in interpreting the impact of serological response on breakthrough infections.
Conclusion:

Vaccination significantly reduces mortality from COVID-19 in hematological patients, but breakthrough infections are prevalent and can be severe, underscoring the need for continuous evaluation of vaccination strategies and ongoing research.

Original Source(s)

One-year breakthrough SARS-CoV-2 infection and correlates of protection in fully vaccinated hematological patients

  • by José Luis Piñana, Lourdes Vazquez, Marisa Calabuig, Lucia López-Corral, Gabriel Martin-Martin, Lucia Villalon, Gabriela Sanz-Linares, Venancio Conesa-Garcia, Andrés Sanchez-Salinas, Beatriz Gago, Ana Facal, Irene Risco-Gálvez, María T. Olave, Ildefonso Espigado, Javier Lopez-Jimenez, José Ángel Hernández-Rivas, Alejandro Avendaño-Pita, Ignacio Arroyo, Elena Ferrer, Irene García-Cadenas, Clara González-Santillana, Alicia Roldán-Pérez, Blanca Ferrer, Manuel Guerreiro, María Suarez-Lledó, Angela Camara, Diana Campos-Beltrán, David Navarro, Ángel Cedillo, Anna Sureda, Carlos Solano, Rodrigo Martino

  • January 5, 2023

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