Clinical outcomes of molecular-targeted therapies for rheumatoid arthritis: comparison between orthopaedic surgeons and rheumatologists in the multicenter retrospective ANSWER cohort - Summary - MDSpire

Clinical outcomes of molecular-targeted therapies for rheumatoid arthritis: comparison between orthopaedic surgeons and rheumatologists in the multicenter retrospective ANSWER cohort

  • By

  • Yuki Etani

  • Yasutaka Okita

  • Kohei Tsujimoto

  • Takaaki Noguchi

  • Koichi Murata

  • Takayuki Fujii

  • Iku Shirasugi

  • Mai Yamashita

  • Koji Nagai

  • Ayaka Yoshikawa

  • Motomu Hashimoto

  • Tadashi Okano

  • Yuji Nozaki

  • Tetsu Itami

  • Yonsu Son

  • Hidehiko Makino

  • Wataru Yamamoto

  • Atsushi Kumanogoh

  • Seiji Okada

  • Ken Nakata

  • Kosuke Ebina

  • April 1, 2026

  • 0 min

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Objective:

To compare treatment retention and clinical outcomes of bDMARDs and JAKi in RA patients treated by orthopaedic surgeons versus rheumatologists, focusing on specific outcomes such as effectiveness and safety.

Key Findings:
  • Significant differences in treatment retention rates were observed between patients treated by orthopaedic surgeons and rheumatologists, suggesting a potential impact on patient outcomes.
  • Reasons for treatment discontinuation varied, with ineffectiveness and adverse events being significant factors, highlighting areas for clinical improvement.
  • Patient characteristics and treatment patterns differed between the two clinical settings, indicating the need for tailored treatment approaches.
Interpretation:

The study suggests that the clinical setting (orthopaedic surgery vs. rheumatology) may influence treatment retention and outcomes in RA patients, underscoring the importance of specialized care in optimizing patient management.

Limitations:
  • The retrospective design may introduce bias, limiting the ability to draw definitive conclusions.
  • Data limited to a specific region in Japan, potentially affecting generalizability to other populations and healthcare systems.
Conclusion:

The findings indicate that treatment outcomes for RA may differ based on the clinical specialty managing the care, warranting further investigation into optimal care models to enhance patient outcomes.

Original Source(s)

Clinical outcomes of molecular-targeted therapies for rheumatoid arthritis: comparison between orthopaedic surgeons and rheumatologists in the multicenter retrospective ANSWER cohort

  • by Yuki Etani, Yasutaka Okita, Kohei Tsujimoto, Takaaki Noguchi, Koichi Murata, Takayuki Fujii, Iku Shirasugi, Mai Yamashita, Koji Nagai, Ayaka Yoshikawa, Motomu Hashimoto, Tadashi Okano, Yuji Nozaki, Tetsu Itami, Yonsu Son, Hidehiko Makino, Wataru Yamamoto, Atsushi Kumanogoh, Seiji Okada, Ken Nakata, Kosuke Ebina

  • April 1, 2026

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