Comparison of percutaneous 60-day peripheral nerve stimulation of the lumbar medial branches to usual care with standard interventional management for chronic low back pain—a multicenter pragmatic randomized controlled trial (RESET) - Summary - MDSpire
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Evaluation of 60-Day Percutaneous Peripheral Nerve Stimulation for Lumbar Medial Branches Versus Standard Interventional Care in Chronic Low Back Pain: Results from a Multicenter Pragmatic Randomized Controlled Trial (RESET)

  • By

  • Zachary L McCormick

  • Denise D Lester

  • Michael J DePalma

  • Christopher A Gilmore

  • Sean Li

  • Jessica B Jameson

  • Mehul J Desai

  • Tristan E Weaver

  • Shivanand P Lad

  • Scott J Davidoff

  • Drew M Trainor

  • Kasra Amirdelfan

  • Mitchell P Engle

  • Timothy R Deer

  • Thomas S Lee

  • Francesco Vetri

  • Meenakshi Bindal

  • Melissa A Tornero-Bold

  • Morad N Nasseri

  • Steven P Cohen

  • William H Clark

  • Meredith J McGee

  • Joseph W Boggs

  • October 25, 2025

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Objective:

To compare the effectiveness of percutaneous 60-day peripheral nerve stimulation (PNS) versus usual care with standard interventional management in patients with chronic low back pain (CLBP).

Key Findings:
  • 55% of participants receiving percutaneous 60-day PNS achieved ≥50% pain relief compared to 26% in the usual care group (P < .001).
  • Greater improvements were observed in secondary endpoints including disability, pain interference, health-related quality of life, and analgesic consumption.
  • Pain reductions and functional improvements were sustained through 6 months in the PNS group.
Interpretation:

Percutaneous 60-day PNS is more effective than standard interventional management for achieving significant pain relief and improving functional outcomes in patients with CLBP.

Limitations:
  • The study was limited to patients with lumbar region pain without radiation to extremities.
  • Results may not be generalizable to all CLBP populations due to specific inclusion criteria.
Conclusion:

Percutaneous 60-day PNS significantly improves pain relief and functional outcomes in CLBP compared to usual care, supporting its use as an effective treatment option.

Original Source(s)

Comparison of percutaneous 60-day peripheral nerve stimulation of the lumbar medial branches to usual care with standard interventional management for chronic low back pain—a multicenter pragmatic randomized controlled trial (RESET)

  • by Zachary L McCormick, Denise D Lester, Michael J DePalma, Christopher A Gilmore, Sean Li, Jessica B Jameson, Mehul J Desai, Tristan E Weaver, Shivanand P Lad, Scott J Davidoff, Drew M Trainor, Kasra Amirdelfan, Mitchell P Engle, Timothy R Deer, Thomas S Lee, Francesco Vetri, Meenakshi Bindal, Melissa A Tornero-Bold, Morad N Nasseri, Steven P Cohen, William H Clark, Meredith J McGee, Joseph W Boggs

  • October 25, 2025

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