Even mild elevations of C-reactive protein levels predict long-term prognosis in heart failure with mildly reduced ejection fraction - Summary - MDSpire

Even mild elevations of C-reactive protein levels predict long-term prognosis in heart failure with mildly reduced ejection fraction

  • By

  • Jonas Dudda

  • Michael Behnes

  • Michelle Goertz

  • Felix Lau

  • Alexander Schmitt

  • Marielen Reinhardt

  • Noah Abel

  • Svetlana Hetjens

  • Daniel Duerschmied

  • Mohammad Abumayyaleh

  • Ibrahim Akin

  • Tobias Schupp

  • June 9, 2026

  • 0 min

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Objective:

To investigate the prognostic impact of C-reactive protein (CRP) levels in patients hospitalized with heart failure with mildly reduced ejection fraction (HFmrEF) regarding long-term all-cause mortality and HF-related rehospitalization.

Approach:
    Key Findings:
    • Elevated CRP levels were associated with increased long-term all-cause mortality and HF-related rehospitalization in patients with HFmrEF.
    • Patients with CRP levels ≥ 50 mg/L had the highest risk of adverse outcomes.
    Interpretation:

    Limitations:
    • The study was conducted at a single center, which may limit generalizability.
    • Exclusion of patients with conditions that could elevate CRP levels may affect the findings.
    Conclusion:

Original Source(s)

Even mild elevations of C-reactive protein levels predict long-term prognosis in heart failure with mildly reduced ejection fraction

  • by Jonas Dudda, Michael Behnes, Michelle Goertz, Felix Lau, Alexander Schmitt, Marielen Reinhardt, Noah Abel, Svetlana Hetjens, Daniel Duerschmied, Mohammad Abumayyaleh, Ibrahim Akin, Tobias Schupp

  • June 9, 2026

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