Efficacy and safety of transoral incisionless fundoplication in non-obese and obese adults: a population-based cohort study from the United States - Summary - MDSpire
Advertisement
Efficacy and safety of transoral incisionless fundoplication in non-obese and obese adults: a population-based cohort study from the United States
To study the real-world effect of BMI on TIF outcomes in adults with class I obesity compared to non-obese patients.
Approach:
Data Source: Utilized the TriNetX US Research Network, a database of electronic medical records from over 70 healthcare organizations.
Study Design: Retrospective cohort study analyzing adult patients diagnosed with GERD who underwent TIF, stratified by BMI.
TIF Procedure Overview: Performed under general anesthesia using the EsophyX device, involving fundoplication techniques to repair the anti-reflux barrier.
Statistical Analysis: Conducted using the TriNetX Live platform, including propensity score matching to minimize confounding.
Key Findings:
TIF has shown efficacy with low adverse event rates in patients with axial hernia < 2 cm.
Combining TIF with cruroplasty demonstrates comparable short-term efficacy and an excellent safety profile.
Obesity is a limitation for TIF, with BMI ≥ 35 kg/m2 being a relative contraindication.
Interpretation:
The study aims to clarify the efficacy and safety of TIF in patients with class I obesity.
Limitations:
Exclusion of patients with BMI > 35 kg/m2 and those with major esophageal motility disorders limits the generalizability of the findings.
Limited literature on the outcomes of TIF in patients with higher BMI.
Conclusion:
Understanding the impact of BMI on TIF outcomes is important given the proportion of patients with class I obesity experiencing GERD.
by Fouad Jaber, Saltenat Moghaddam Adames, Mohamed Jaber, Kinan Obiedat, Kalpesh Patel, Teminioluwa A. Ajayi, Roy Tomas DaVee, Fares W. Ayoub, Nirav Thosani, Wasseem Skef
