Independent prognostic value of the triglyceride–glucose index and its incremental predictive contribution beyond traditional risk markers in acute heart failure: a retrospective cohort study - Summary - MDSpire
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Independent prognostic value of the triglyceride–glucose index and its incremental predictive contribution beyond traditional risk markers in acute heart failure: a retrospective cohort study
To evaluate the association between the triglyceride–glucose (TyG) index and adverse outcomes in patients with acute heart failure, and to assess its independent prognostic value compared to NT-proBNP in terms of predictive performance.
Key Findings:
184 patients experienced the composite endpoint during follow-up.
Higher TyG levels were independently associated with an increased risk of the composite endpoint (HR = 1.74, 95% CI: 1.35–2.25, P < 0.001).
Patients in the highest TyG quartile had a significantly higher risk compared to those in the lowest quartile (HR = 2.17, 95% CI: 1.34–3.50).
TyG demonstrated a discriminative ability comparable to NT-proBNP, with a combined model achieving a higher area under the curve.
Threshold effect analysis identified a significant threshold at TyG = 9.659.
Interpretation:
TyG is independently associated with adverse composite outcomes in patients with acute heart failure.
Limitations:
Single-center study may limit generalizability; results may not apply to broader populations.
Retrospective design may introduce selection bias, affecting the reliability of the findings.
Conclusion:
TyG may provide additional prognostic information in patients with acute heart failure beyond traditional biomarkers, suggesting its potential role in clinical risk stratification.
