Overcoming absolute dysphagia in a thirty-year-old patient with advanced anaplastic lymphoma kinase-positive non-small cell lung cancer: a case report - Summary - MDSpire

Overcoming absolute dysphagia in a thirty-year-old patient with advanced anaplastic lymphoma kinase-positive non-small cell lung cancer: a case report

  • By

  • Luca Carlofrancesco Ammoni

  • Giorgia Carola

  • Giuseppe Ippolito

  • Alice Baggi

  • Francesca Consoli

  • Andrea Esposito

  • Ilaria Pedrazzini

  • Alfredo Berruti

  • Salvatore Grisanti

  • May 28, 2026

  • 0 min

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Objective:

To report a case of a young woman with advanced ALK-positive NSCLC who experienced severe dysphagia.

Key Findings:
  • Rapid reduction of cervical lymph node swelling was observed within days of lorlatinib administration.
  • Swallowing improved, and the patient resumed oral intake.
  • Imaging showed a partial response at two weeks and a complete metabolic response at six months.
Interpretation:

Limitations:
  • No formal evidence exists for alternative formulations of lorlatinib.
  • The study is based on a single case report.
Conclusion:

Crushed lorlatinib administered through a nasogastric tube is an option for dysphagic patients with ALK-positive NSCLC.

Original Source(s)

Overcoming absolute dysphagia in a thirty-year-old patient with advanced anaplastic lymphoma kinase-positive non-small cell lung cancer: a case report

  • by Luca Carlofrancesco Ammoni, Giorgia Carola, Giuseppe Ippolito, Alice Baggi, Francesca Consoli, Andrea Esposito, Ilaria Pedrazzini, Alfredo Berruti, Salvatore Grisanti

  • May 28, 2026

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