To investigate the associations between serum and follicular fluid oxytocin levels and live birth rate (LBR) in IVF cycles, emphasizing the potential impact on clinical practices.
Key Findings:
Serum oxytocin showed a negative linear association with LBR (p < 0.001).
Follicular fluid oxytocin demonstrated a positive association with LBR (p < 0.01).
Each 100 pg/mL increase in serum oxytocin decreased the likelihood of live birth by 37% (95% CI: 25%–47%).
Each 100 pg/mL increase in follicular fluid oxytocin improved the likelihood of live birth by 18% (95% CI: 2%–37%).
Serum oxytocin correlated positively with triglycerides, LDL-C, and insulin, but negatively with HDL-C.
Follicular fluid oxytocin correlated positively with ovarian response markers.
Interpretation:
Higher serum oxytocin levels prior to ovarian stimulation are negatively associated with LBR, while elevated follicular fluid oxytocin correlates with improved ovarian response, suggesting potential clinical implications for IVF protocols.
Limitations:
Study limited to a specific time frame and population, which may affect generalizability.
Exclusion criteria may limit the diversity of the sample and the applicability of findings.
Conclusion:
The study highlights the distinct roles of serum and follicular fluid oxytocin in relation to IVF outcomes, suggesting avenues for future research and clinical application.
