To systematically summarize the regulatory mechanisms of LDHA in immune cell metabolism and anti-tumor immunity, and discuss its clinical potential as a therapeutic target, particularly in combination with existing immunotherapies.
Approach:
Key Findings:
LDHA is overexpressed in various human malignancies and plays a crucial role in tumor metabolism and immune cell modulation.
LDHA-mediated lactate production influences immune cell viability, functions, and polarization towards pro-inflammatory or immunosuppressive phenotypes.
Differential expression of LDHA in immune cells regulates their metabolic reprogramming and impacts anti-tumor immune responses.
Interpretation:
The review highlights the importance of LDHA in shaping the tumor immune microenvironment and suggests its potential as a target for combined immunotherapy strategies, including CAR-T therapy and immune checkpoint blockade.
Limitations:
Most studies have focused on LDHA's role in tumor cells rather than its effects on immune cells, particularly in T cells and macrophages.
Limited literature systematically summarizes the differential expression profiles of LDHA across various immune cell subsets.
Conclusion:
The findings provide a theoretical basis for developing LDHA-targeted therapies in tumor immunotherapy, addressing current challenges in the field.
