To evaluate the association of different NTIS subtypes and thyroid autoantibodies with mortality in septic patients.
Key Findings:
82% of patients had NTIS, which was linked to higher age, comorbidities, and SOFA scores.
NTIS was an independent predictor of in-hospital mortality (OR 3.14).
NTIS-1 and NTIS-2 subtypes were associated with approximately fourfold higher mortality risk.
TGAb positivity was a strong predictor of mortality (OR 2.15), while TPOAb showed a trend but was not statistically significant.
Interpretation:
NTIS is prevalent in sepsis and predicts mortality, with specific subtypes indicating higher risk. Thyroid autoantibodies, particularly TGAb, further enhance mortality risk assessment.
Limitations:
Single-center study may limit generalizability.
Retrospective design may introduce selection bias.
Conclusion:
Incorporating thyroid function tests and antibody measurements can improve risk stratification in septic patients.
