Objective:

To systematically evaluate the impact of transcutaneous auricular vagus nerve stimulation (taVNS) on motor function, psychological well-being, and activities of daily living (ADL) in stroke patients, specifically measuring improvements in these areas.

Key Findings:

• taVNS significantly improved motor function scores (SMD = 1.21; 95% CI: 0.88–1.55; p < 0.001).
• Enhanced mental health scores were observed (SMD = 0.84; 95% CI: 0.49–1.19; p < 0.001).
• Improved ADL scores (SMD = 0.94; 95% CI: 0.72–1.17; p < 0.001).
• Notable differences in neurophysiological metrics (SMD = 1.60; 95% CI: 0.70–2.51; p = 0.0005).
• Subgroup analysis showed better outcomes with 20 Hz taVNS and at least 10 sessions.

Interpretation:

taVNS is effective in enhancing various functional outcomes in stroke recovery, with specific stimulation parameters influencing its effectiveness.

Limitations:

• The sample size of included studies is relatively small, which may limit the generalizability of the findings.
• Heterogeneity in stimulation parameters and patient demographics may affect the applicability of results across different populations.

Conclusion:

taVNS is a promising noninvasive intervention that can improve motor abilities, psychological well-being, and ADL in stroke patients, warranting further research to explore its full potential and optimize treatment protocols.

Sources:

• Systematic Review Registration