To investigate the penile microbiome in male patients with histopathologically confirmed lichen sclerosus compared to a control group with healthy foreskin and a non-LS group, clarifying the differences in microbiome composition.
Key Findings:
Most prevalent bacteria in uncircumcised males include Corynebacterium spp., Prevotella, and Staphylococcus, indicating a potential risk factor for infections.
Higher prevalence of pathogenic bacteria in uncircumcised men compared to circumcised individuals, suggesting implications for clinical management.
Lichen sclerosus is associated with chronic inflammation and phimosis, affecting predominantly uncircumcised males, highlighting the need for targeted interventions.
Interpretation:
The study aims to clarify the role of the microbiome in the pathogenesis of lichen sclerosus, addressing gaps in previous research focused on vulvar LS and urethral strictures, and providing insights into potential therapeutic targets.
Limitations:
Limited to a single centre, which may affect generalizability of the findings.
Exclusion of patients with recent antibiotic use may limit understanding of microbiome dynamics and its fluctuations.
Conclusion:
The findings may provide insights into the microbiome's role in lichen sclerosus and its potential implications for treatment and management, suggesting avenues for future research.
