Clinical profile of headache attributed to anxiety and depressive disorders: an observational study - Summary - MDSpire

Clinical profile of headache attributed to anxiety and depressive disorders: an observational study

  • By

  • Boyan Chen

  • Sailucao Zhang

  • Jing Yang

  • Xinyu Yan

  • Chunyu Wang

  • Dongjun Wan

  • May 18, 2026

  • 0 min

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Objective:

To systematically characterize the clinical features of headache attributed to anxiety and depressive disorders (HA-ADD) for better recognition and management, emphasizing the importance of early diagnosis.

Key Findings:
  • Predominantly female cohort (70.3%) with a median age of 36 years.
  • Characteristic HA-ADD phenotype: bilateral pain (72.3%), dull quality (92.1%), moderate-to-severe intensity (53.5% moderate; 42.6% severe).
  • Common locations: temporal (47.5%) and parietal (35.6%).
  • 60.4% of attacks lasted less than 4 hours.
  • Associated symptoms included phonophobia (79.2%), restlessness/agitation (58.4%), dizziness (57.4%), and nausea (51.5%).
  • Emotional fluctuations (71.3%) and poor sleep quality (57.4%) were predominant triggers.
  • 73.2% of patients experienced severe headache-related functional impairment (HIT-6 score >60).
  • Exclusion criteria included a history of any diagnosis meeting the ICHD-3 criteria for primary headache disorders.
Interpretation:

HA-ADD presents a distinct clinical profile that differentiates it from common primary headache disorders, highlighting the need for specific diagnostic and therapeutic approaches, which could improve patient outcomes.

Limitations:
  • Study conducted at a single center, limiting generalizability.
  • Reliance on patient recall for headache and mood symptom correlation may introduce bias, potentially affecting the accuracy of findings.
Conclusion:

The study provides a detailed characterization of HA-ADD, which may facilitate earlier diagnosis and appropriate treatment interventions, underscoring the need for further research in this area.

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