Predictors of Treatment Failure in Outpatient Management of Uncomplicated Skin and Soft Tissue Infections: Findings from a Prospective Multicenter Study in Türkiye - Summary - MDSpire

Predictors of Treatment Failure in Outpatient Management of Uncomplicated Skin and Soft Tissue Infections: Findings from a Prospective Multicenter Study in Türkiye

  • By

  • Melike Nur Özçelik

  • Merve Sefa Sayar

  • Nurten Nur Aydın

  • Dilşah Başkol Elik

  • Özgür Günal

  • Pınar Yürük Atasoy

  • Ayşegül Tuna

  • Cihan Semet

  • Serpil Erol

  • Azize Yetişgen

  • Yakup Gezer

  • Muhammet Rıdvan Tayşi

  • Naciye Betül Baysal

  • Gülden Eser Karlıdağ

  • Muammer Çelik

  • Emsal Aydın

  • Yeşim Kürekçi

  • Yasemin Akkoyunlu

  • Özay Akyıldız

  • Ayşe Serra Özel

  • Oktay Yapıcı

  • Deniz Özer

  • Şafak Kaya

  • Tuba Damar Çakırca

  • Şafak Balın Özer

  • İsmail Necati Hakyemez

  • December 27, 2025

  • 0 min

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Objective:

To identify predictors of outpatient treatment failure in uncomplicated skin and soft tissue infections (uSSTIs) to optimize treatment duration and minimize hospitalization, focusing on specific metrics such as readmission rates and symptom resolution times.

Key Findings:
  • Higher BMI, chronic kidney disease, immunodeficiency, insect bite etiology, and smoking were identified as significant risk factors for hospitalization, highlighting the need for targeted interventions.
  • Clinical predictors included preseptal cellulitis, lesion size > 10% BSA, elevated pulse rate, and higher risk scores (LRINEC, CREST/ERON, modified Dundee), indicating areas for close monitoring.
  • Laboratory predictors included elevated WBC, NLR, CRP, procalcitonin, and decreased hemoglobin, which can guide early clinical decisions.
Interpretation:

Identifying specific risk factors and clinical/laboratory predictors can help in early identification of patients at risk for treatment failure, potentially guiding more effective outpatient management strategies and reducing hospitalization rates.

Limitations:
  • Limited microbiological data due to inclusion criteria focused on patients eligible for culture, which may affect the understanding of pathogen-specific treatment responses.
  • The study's findings may not be generalizable beyond the specific population and settings in Türkiye, necessitating further research in diverse populations.
Conclusion:

The study highlights the importance of recognizing predictors of treatment failure in uSSTIs to optimize outpatient management and reduce unnecessary hospitalizations, ultimately improving patient outcomes.

Original Source(s)

Predictors of Treatment Failure in Outpatient Management of Uncomplicated Skin and Soft Tissue Infections: Findings from a Prospective Multicenter Study in Türkiye

  • by Melike Nur Özçelik, Merve Sefa Sayar, Nurten Nur Aydın, Dilşah Başkol Elik, Özgür Günal, Pınar Yürük Atasoy, Ayşegül Tuna, Cihan Semet, Serpil Erol, Azize Yetişgen, Yakup Gezer, Muhammet Rıdvan Tayşi, Naciye Betül Baysal, Gülden Eser Karlıdağ, Muammer Çelik, Emsal Aydın, Yeşim Kürekçi, Yasemin Akkoyunlu, Özay Akyıldız, Ayşe Serra Özel, Oktay Yapıcı, Deniz Özer, Şafak Kaya, Tuba Damar Çakırca, Şafak Balın Özer, İsmail Necati Hakyemez

  • December 27, 2025

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