To assess the prospective associations between four TyG-based parameters and the incidence of liver-related events (LRE), such as cirrhosis and hepatocellular carcinoma, among individuals with type 2 diabetes (T2D).
Key Findings:
507 T2D patients developed LRE during a median follow-up of 13.4 years.
Higher quartiles of TyG-WC (HR = 1.63, 95% CI 1.12-2.38) and TyG-WHtR (HR = 1.98, 95% CI 1.36-2.89) were associated with increased LRE risk.
No significant associations were found for TyG and TyG-BMI with LRE risk.
Stronger associations for TyG-WC/TyG-WHtR were observed in high-risk populations, including excessive alcohol consumers and individuals with FIB-4 scores ≥1.3.
Interpretation:
TyG-WC and TyG-WHtR indices are independently associated with increased risk of LRE in T2D patients, suggesting their potential as practical tools for risk stratification in clinical settings.
Limitations:
The study is observational, which limits causal inferences and may introduce biases.
Potential confounding factors may not have been fully controlled.
Conclusion:
TyG-WC and TyG-WHtR may serve as efficient and cost-effective tools for identifying and stratifying LRE risk in clinical practice among T2D patients, warranting further research to validate these findings.
