Objective:

To explore the related influencing factors of recurrent acute pancreatitis in children and provide a reference for clinical early identification of high-risk children with recurrent acute pancreatitis (RAP), emphasizing the significance of early detection.

Key Findings:

• Significant differences in triglyceride, high density lipoprotein, blood glucose, and D-dimer levels between the two groups (P < 0.05).
• HDL, blood glucose, and D-dimer were identified as independent factors for RAP, with specific odds ratios and confidence intervals.
• Combined diagnostic model showed high predictive efficacy with an AUC of 0.943 (95% CI: 0.902–0.983).

Interpretation:

HDL serves as a protective factor against RAP, while blood glucose and D-dimer are risk factors; the combined detection of these indicators enhances early diagnosis accuracy, with HDL's protective role explained.

Limitations:

• Retrospective design may introduce bias.
• Study conducted at a single center, limiting generalizability.
• Potential confounding factors may not have been controlled for.

Conclusion:

Clinical combined detection of HDL, blood glucose, and D-dimer can improve early diagnosis of RAP and guide interventions for high-risk children, highlighting the clinical implications of these findings.