Epilepsy characteristics and outcomes in patients with pleomorphic xanthoastrocytomas - Summary - MDSpire

Epilepsy characteristics and outcomes in patients with pleomorphic xanthoastrocytomas

  • By

  • Cody L. Nathan

  • Dina Ghandour

  • Elizabeth M. Cunningham

  • Rimas V. Lukas

  • Jared Sullivan

  • Sean Sachdev

  • Jessica W. Templer

  • June 19, 2026

  • 0 min

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Objective:

To explore clinical, pathologic, and EEG features that may impact seizure outcomes in patients with PXAs and tumor-related epilepsy.

Approach:
    Key Findings:
    • 76% of patients with PXA had tumor-related epilepsy.
    • The mean age at diagnosis was 32 years, with a range of 10 to 71 years.
    • The most frequent tumor location was the temporal lobe (47.4%).
    • Higher initial tumor volume trended towards worse seizure outcomes, but this was not statistically significant.
    • Gross total resection was performed in 57.8% of patients.
    Interpretation:

    Limitations:
    • Small sample size of 25 patients.
    • Limited statistical significance for some findings.
    • Potential biases in retrospective data collection.
    Conclusion:

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