Objective:

To investigate the association between the triglyceride–glucose (TyG) index and subclinical atherosclerosis (SA) in asymptomatic adults.

Approach:

Key Findings:

• Higher TyG levels were associated with increased odds of SA in a dose–response pattern.
• Each 1-unit increase in TyG was associated with 20% higher odds of SA (OR 1.20, 95% CI 1.10–1.30).
• Participants in the highest tertile had increased odds of SA compared to the lowest tertile (OR 1.38, 95% CI 1.22–1.56; Ptrend <0.001).
• RCS analysis indicated a significant non-linear association (Pnon−linearity = 0.034) with an inflection point around 8.07.
• The association remained consistent in normoglycemic individuals (OR = 1.21; 95% CI: 1.02–1.44).

Interpretation:

The TyG index shows a positive association with SA in a large asymptomatic population.

Limitations:

• The non-linear pattern requires further validation.
• The study is cross-sectional, limiting causal inferences.

Conclusion:

The findings provide insights into the association between TyG index and SA.

Attribution Notice

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