Computed tomography findings in 11,504 adult patients with traumatic brain injury: a large real-world cohort study with a S100B subgroup analysis - Summary - MDSpire
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Computed tomography findings in 11,504 adult patients with traumatic brain injury: a large real-world cohort study with a S100B subgroup analysis
To characterize acute cranial CT findings in a large cohort of adult patients with traumatic brain injury and to explore the diagnostic performance of S100B in a selected subgroup.
Approach:
Study Design: Retrospective single-center cohort study evaluating adult patients presenting with TBI to a level I trauma center between April 2016 and May 2024.
Inclusion Criteria: Patients aged 18 and older with documented TBI and cranial CT examination.
Data Acquisition: Patient-level data extracted from the hospital information system, including age, sex, diagnoses, treatment status, CT findings, and S100B measurements.
Key Findings:
A significant proportion of cranial CT scans in adult TBI patients did not demonstrate acute traumatic abnormalities.
Negative S100B levels were associated with the absence of acute findings on CT in a selected subgroup.
Interpretation:
Many CT scans in TBI patients did not demonstrate acute traumatic abnormalities, and negative S100B levels were associated with the absence of acute findings on CT in a selected subgroup.
Limitations:
The study was conducted at a single center, which may limit generalizability.
Retrospective design may introduce selection bias.
Conclusion:
The findings indicate that a significant proportion of cranial CT scans in adult TBI patients did not show acute traumatic abnormalities.
