Systematic Review of Urinary Biomarkers for the Detection of Renal Cell Carcinoma - Summary - MDSpire

Systematic Review of Urinary Biomarkers for the Detection of Renal Cell Carcinoma

  • By

  • Jaycey F. Kelly

  • Iryna V. Samarska

  • Bram Ramaekers

  • Tom Marcelissen

  • Joep G. van Roermund

  • Maureen J. B. Aarts

  • Thomas Kerkhofs

  • Tom Hermans

  • Frits van Osch

  • Tim de Meyer

  • Leo J. Schouten

  • Kim M. Smits

  • October 30, 2025

  • 0 min

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Objective:

To identify and evaluate urinary biomarkers for the early detection of sporadic renal cell carcinoma (RCC) and assess their diagnostic properties.

Key Findings:
  • 46 studies were included, with STROBE scores ranging from 8.5 to 17.5, indicating variable quality.
  • Selection bias was the most common type of bias identified in the studies.
  • Biomarkers with an AUC of ≥ 0.80 were considered promising for clinical utility.
Interpretation:

Despite the identification of several promising urinary biomarkers for RCC, challenges remain in their clinical application due to issues like validation and standardization.

Limitations:
  • Many studies exhibited selection bias, affecting the reliability of findings.
  • No studies achieved the maximal STROBE score, indicating potential deficiencies in reporting quality.
Conclusion:

The review highlights the need for further validation and standardization of urinary biomarkers to enhance their clinical utility in RCC detection.

Original Source(s)

Systematic Review of Urinary Biomarkers for the Detection of Renal Cell Carcinoma

  • by Jaycey F. Kelly, Iryna V. Samarska, Bram Ramaekers, Tom Marcelissen, Joep G. van Roermund, Maureen J. B. Aarts, Thomas Kerkhofs, Tom Hermans, Frits van Osch, Tim de Meyer, Leo J. Schouten, Kim M. Smits

  • October 30, 2025

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