Cytokine and Humoral Immune Responses to a Goatpox Vaccine in Mithun (Bos frontalis): A Year-Long Field Investigation - Summary - MDSpire

Cytokine and Humoral Immune Responses to a Goatpox Vaccine in Mithun (Bos frontalis): A Year-Long Field Investigation

  • By

  • Gundallahalli Bayyappa Manjunatha Reddy

  • Vikram Ramesh

  • Yallappa M. Somagond

  • Plabita Goswami

  • Selvaraj Ragulraj

  • Hlawndo Lalzampuia

  • Suchismitha Pal

  • Sudeep Nagaraj

  • Sunil Tadakod

  • Uzma Jabeen

  • Shraddha Bijalwan

  • Muthannan Andavar Ramakrishnan

  • Baldev Raj Gulati

  • Patil Shivanagowda Girish

  • April 21, 2026

  • 0 min

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Objective:

To assess the safety and vaccine-induced immune response of a goatpox vaccine in seronegative Mithun over a 12-month period, specifically focusing on its heterologous nature.

Key Findings:
  • The goatpox vaccine was safe with no adverse reactions or viral shedding observed.
  • Seroconversion and cytokine upregulation were noted, peaking at 30 days post-vaccination.
  • Spatial mapping indicated ongoing Lumpy Skin Disease Virus (LSDV) activity in Mithun populations, suggesting a need for continued monitoring.
Interpretation:

The study provides evidence of effective humoral and cytokine immune responses to the goatpox vaccine in Mithun, suggesting its potential for controlling Lumpy Skin Disease (LSD) in this species, which is crucial for livestock health and economic stability.

Limitations:
  • Antigen-specific cell-mediated immunity was not assessed.
  • The study was limited to a specific geographic area (Nagaland) and a small sample size (26 Mithun).
Conclusion:

This research establishes a baseline for future evaluations of LSD control strategies in Mithun and highlights the critical need for further studies on cell-mediated immunity to fully understand the vaccine's efficacy.

Original Source(s)

Cytokine and Humoral Immune Responses to a Goatpox Vaccine in Mithun (Bos frontalis): A Year-Long Field Investigation

  • by Gundallahalli Bayyappa Manjunatha Reddy, Vikram Ramesh, Yallappa M. Somagond, Plabita Goswami, Selvaraj Ragulraj, Hlawndo Lalzampuia, Suchismitha Pal, Sudeep Nagaraj, Sunil Tadakod, Uzma Jabeen, Shraddha Bijalwan, Muthannan Andavar Ramakrishnan, Baldev Raj Gulati, Patil Shivanagowda Girish

  • April 21, 2026

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