CD19-negative non-IgM type lymphoplasmacytic lymphoma: a case report and literature review - Summary - MDSpire

CD19-negative non-IgM type lymphoplasmacytic lymphoma: a case report and literature review

  • By

  • Feng Lu

  • Fugang Li

  • Hongying Zhan

  • Yuanfeng Huang

  • Rong Huang

  • Xuchuan Jiang

  • Chengjie Ji

  • Gang Wang

  • Tao Chen

  • Xia Fu

  • Tao Wei

  • Weijie Jiang

  • July 13, 2026

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Objective:

To report a rare case of CD19-negative non-IgM type lymphoplasmacytic lymphoma (LPL) and discuss the diagnostic challenges associated with this atypical immunophenotype.

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Key Findings:
  • The patient exhibited elevated serum IgG and an IgG-λ monoclonal protein.
  • Bone marrow biopsy revealed normocellular marrow with approximately 40% cellularity and no characteristic lymphoid aggregates.
  • Flow cytometry identified a CD19-negative, CD20-positive monoclonal B lymphocyte population.
Interpretation:

The case highlights the importance of a multi-platform diagnostic approach in identifying atypical immunophenotypes in hematologic malignancies.

Limitations:
  • The study is based on a single case report, limiting generalizability.
  • Potential for misdiagnosis due to the atypical immunophenotype of CD19-negative clonal populations.
Conclusion:

Accurate diagnosis of non-IgM type LPL requires integration of morphological, immunophenotypic, and molecular findings.

Original Source(s)

CD19-negative non-IgM type lymphoplasmacytic lymphoma: a case report and literature review

  • by Feng Lu, Fugang Li, Hongying Zhan, Yuanfeng Huang, Rong Huang, Xuchuan Jiang, Chengjie Ji, Gang Wang, Tao Chen, Xia Fu, Tao Wei, Weijie Jiang

  • July 13, 2026

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