To summarize the current evidence on the effect of dietary fiber supplementation on endogenous GLP-1 secretion and satiety.
Approach:
Literature Search: A pre-registered scoping review was conducted using PubMed, Scopus, and Cochrane Central, focusing on randomized controlled trials in adults.
Study Inclusion: Included studies assessed circulating GLP-1 concentrations and satiety following supplementation with a single, well-defined dietary fiber.
Data Analysis: Outcomes were summarized qualitatively across fiber categories, with a total of 49 publications comprising 52 studies included.
Key Findings:
1049 papers screened, 49 publications included with a total of 1,085 participants.
71% of studies were acute interventions conducted in Western populations.
Dextrins showed robust effects on both GLP-1 and satiety.
Other fibers like β-glucans and mannans showed effects on either satiety or GLP-1, but not both.
Interpretation:
The evidence suggests dextrins may be a promising dietary fiber for enhancing GLP-1 secretion and satiety, but findings are limited by small sample sizes and short intervention durations.
Limitations:
Small sample sizes across studies.
Short duration of interventions.
Substantial heterogeneity in study designs and populations.
Conclusion:
Longer-term studies in free-living conditions are needed to capture microbiota adaptation and generate robust evidence.
In a pooled analysis of two randomized crossover trials, reducing nightly sleep by about 1.5 hours for 6 weeks was associated with modest increases in body weight and waist circumference without measurable changes in body composition.
