Objective:

To elucidate the effect of triglyceride glucose-body mass index (TyG-BMI) on 90-day poor outcomes in acute ischemic stroke (AIS) individuals.

Key Findings:

• TyG-BMI did not show a linear correlation with 90-day poor outcomes in the overall AIS cohort.
• A nonlinear effect of TyG-BMI on 90-day poor outcomes was identified, with an inflection point at a TyG-BMI value of 193.59.
• For TyG-BMI values ≤ 193.59, there was a negative association with 90-day unfavorable outcomes (OR = 0.65).
• For TyG-BMI values > 193.59, the effect on 90-day unfavorable outcomes was not statistically significant (OR = 1.16).

Interpretation:

A nonlinear relationship and threshold effect between TyG-BMI and 90-day unfavorable outcomes in AIS patients were observed.

Limitations:

• The study is based on a single-center cohort, which may limit generalizability.
• The retrospective design may introduce biases not present in prospective studies.

Conclusion:

TyG-BMI ≤ 193.59 is associated with a negative effect on 90-day outcomes in AIS patients, while values exceeding this threshold do not show significant association.